| Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans | |
| 論文作者 | Wang, XQ; Jiang, QL; Zhang, HD; He, ZD; Song, YY; Chen, YF; Tang, N; Zhou, YF; Li, YP; Antebi, A; Wu, LG; Han, JDJ; Shen, YD |
| 期刊/會議名稱 | NATURE COMMUNICATIONS |
| 論文年度 | 2024 |
| 論文類別 | |
| 摘要 | Ageing exhibits common and distinct features in various tissues, making it critical to decipher the tissue-specific ageing mechanisms. MiRNAs are essential regulators in ageing and are recently highlighted as a class of intercellular messengers. However, little is known about the tissue-specific transcriptomic changes of miRNAs during ageing. C. elegans is a well-established model organism in ageing research. Here, we profile the age-dependent miRNAomic changes in five isolated worm tissues. Besides the diverse ageing-regulated miRNA expression across tissues, we discover numerous miRNAs in the tissues without their transcription. We further profile miRNAs in the extracellular vesicles and find that worm miRNAs undergo inter-tissue trafficking via these vesicles in an age-dependent manner. Using these datasets, we uncover the interaction between body wall muscle-derived mir-1 and DAF-16/FOXO in the intestine, suggesting mir-1 as a messenger in inter-tissue signalling. Taken together, we systematically investigate worm miRNAs in the somatic tissues and extracellular vesicles during ageing, providing a valuable resource to study tissue-autonomous and nonautonomous functions of miRNAs in ageing. |
| 期 | 1 |
| 卷 | 15 |
| 影響因子 | 14.7 |
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