郵箱: lxzhan@sinh.ac.cn
電話: +86-21-54920978
所屬部門: 營(yíng)養(yǎng)代謝與食品安全重點(diǎn)實(shí)驗(yàn)室
2017-至 今：中國(guó)科學(xué)院上海營(yíng)養(yǎng)與健康研究所 研究員
2010-2016年：中國(guó)科學(xué)院上海生命科學(xué)研究院營(yíng)養(yǎng)科學(xué)研究所?研究員
2004-2010年：美國(guó)冷泉港實(shí)驗(yàn)室 博士后
1998-2003年：中國(guó)人民解放軍第二軍醫(yī)大學(xué) 內(nèi)科學(xué)專業(yè) 博士
1991-1996年：浙江醫(yī)科大學(xué) 臨床醫(yī)學(xué)專業(yè) 學(xué)士
上皮穩(wěn)態(tài)失衡與腫瘤
1.?上皮極性/穩(wěn)態(tài)調(diào)控與腫瘤
聚焦上皮極性基因的功能機(jī)制，系統(tǒng)解析以下四方面的細(xì)胞生物學(xué)問題：（1）極性信號(hào)在上皮穩(wěn)態(tài)維持中的核心作用；（2）極性信號(hào)與亞細(xì)胞結(jié)構(gòu)功能調(diào)控（例如線粒體和細(xì)胞骨架）的關(guān)系以及在上皮細(xì)胞能量代謝中的作用；（3）具有雙定位功能的極性信號(hào)行使入核調(diào)控功能的重要意義；（4）探究基質(zhì)剛度、組織壓力等力學(xué)微環(huán)境破壞上皮細(xì)胞功能、并促進(jìn)腫瘤進(jìn)展的力學(xué)生物學(xué)機(jī)制。通過以上四方面的研究，解析極性蛋白丟失協(xié)同致癌突變驅(qū)動(dòng)腫瘤發(fā)生的代謝重構(gòu)以及腫瘤微環(huán)境調(diào)控的機(jī)制。
2.?硒穩(wěn)態(tài)失衡與腫瘤發(fā)生
深入研究微量元素硒及硒蛋白家族因子在腫瘤氧化代謝壓力下的多層次調(diào)控規(guī)律，通過線粒體蛋白調(diào)控細(xì)胞死亡、炎癥以及與免疫代謝中全新機(jī)制探討，試圖解析腫瘤代謝重編程以及表觀遺傳調(diào)控規(guī)律，以明確其在腫瘤惡性轉(zhuǎn)化中通過對(duì)腫瘤細(xì)胞衰老等方式實(shí)現(xiàn)改善腫瘤免疫微環(huán)境的免疫抑制作用，將為硒抗腫瘤免疫干預(yù)提供新的臨床治療干預(yù)方案和新靶點(diǎn)。
3.?上皮穩(wěn)態(tài)與肝胰代謝性疾病
以肝胰上皮屏障為核心，研究上皮屏障紊亂與糖脂代謝微環(huán)境的相互調(diào)控機(jī)制，解析慢性代謝疾病中的免疫 - 代謝串?dāng)_規(guī)律，揭示肝屏障功能異常介導(dǎo)的以下病理生理過程：脂肪干細(xì)胞趨化分化等功能失衡、代謝紊亂與慢性免疫代謝微環(huán)境的關(guān)系及其炎癥的分子基礎(chǔ)，從而發(fā)掘慢性肝病及代謝綜合征防治的新靶標(biāo)與新策略。
1.?Jiazheng Jiao, Lele Song, Shengjun Xu, Yuan Xue, Yanyan Liao, Keying Xu, Qian Wen, Kai Xiang, Rongrong Chen, Xiaoxia Dong, Yinlong Guo, Gang Li*, Haibiao Bao*, Xiao Xu*,?Lixing Zhan*. Selenoprotein P Deficiency Drives Hepatocellular Carcinoma Progression via Induction of Neutrophil Senescence and Immunosuppressive Microenvironment. Gut.?2026, online. doi:?10.1136/gutjnl-2025-336422
2.?Keying Xu, Xiaoxia Dong, Huiheng Qu, Jiayang Hu, Jiazheng Jiao, Rongrong Chen, Gang Li*, Zhaoshen Li*, Xiao Xu*, Jiazeng Xia*, and Lixing Zhan*. AF6 knockout-induced upregulation of bile acid production promotes CXCL14-mediated antitumor immunity in HCC. Journal of Hepatology. 2026, 84(5): 976-992.
3.?Yingchao Liu, Jiahui Bai, Xiaoxia Dong, Yuqi Cao, Mingmai Bao, Yingjie Lu, Hui Zeng, Lixing Zhan*, Yinlong Guo*. Online Charge-Generation Derivatization by?Electrochemical Radical Cations of ?Thianthrene: Mass Spectrometry Imaging of?Estrogens in Biological Tissues. Analytical Chemistry. 2024, 96, 30, 12473–12481.
4.?Xiuqi Gui,?Jing Huang,?Linjie Ruan,?Yanjun Wu,?Xuan Guo,?Ruifang Cao,?Shuhan Zhou,?Fengxiang Tan,?Hongwen Zhu,?Mushan Li,?Guoqing Zhang,?Hu Zhou,?Lixing Zhan*,?Xin Liu*,?Shiqi Tu*,?Zhen Shao*.?zMAP toolset: model-based analysis of large-scale proteomic data via a variance stabilizing?z-transformation.?Genome Biol. 2024,?25(1):?267.
5.?Xinyu?Wang,?Qian?Wen,?Yanjun?Wu,?Jingwen?Kong,?Keying?Xu,?Jiazheng?Jiao,?Haibing?Zhang*,?Kai?Wang*,?Xiao?Xu*, Lixing?Zhan*. Polarity protein AF6 functions as a modulator of necroptosis by regulating ubiquitination of RIPK1 in liver diseases. Cell Death and Disease,?2023, 14:673.
6.?Yanjun Wu,?Lele Song,?Jingwen Kong,?Qian Wen,?Jiazheng Jiao,?Xinyu Wang,?Gang Li,?Xiao Xu*,?Lixing Zhan*. Scribble promotes fibrosis-dependent mechanisms of hepatocarcinogenesis by p53/PUMA-mediated glycolysis. Biochim Biophys Acta Mol Basis Dis, 2023, 1869(8):166823.
7.?Meiyan Qi, Yun Xia, Yanjun Wu, Zhuo Zhang, Xinyu Wang, Liying Lu, Cheng Dai, Yanan Song, Keying Xu, Weiwei Ji,?Lixing Zhan*.?Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer??progression. Nature Communications, 2022, 13:897.
8.?Lele Song, Renxu Chang, Xia Sun; Liying Lu, Han Gao, Huiying Lu, Ritian Lin, ?Xiaorong Xu, Zhanju Liu*, Lixing Zhan*. Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice, Communications Biology. 2021, 4(1): 213.?
9.?Cheng Dai, Xinyu Wang, Yanjun Wu, Yi Xu, Shu Zhuo, Meiyan Qi, Weiwei Ji, Lixing Zhan*. Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in a SHP2-dependent Manner. Diabetes.?2019,?68:1577-1590.??
10.?Na Wang, Lele Song, Yi Xu, Longfu Zhang, Yanjun Wu, Jingyu Guo, Weiwei Ji, Li Li, Jingya Zhao, Xin Zhang*, Lixing Zhan*. Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling. EBioMedicine.?2019,47:65-77.??
11.?Renxu?Chang,?Lele?Song, Yi?Xu, Yanjun?Wu, Cheng?Dai, Xinyu?Wang, Xia?Sun, Yingyong?Hou,?Wei?Li, Xiaobao?Zhan, Zhan,Lixing*, Loss of Wwox drives metastasis 1 in triple-negative breast cancer by upregulating the IL6/JAK2/STAT3 axis, Nature Communications. 2018,?9:3486.???
12.?Xiaojiao?Li, Lele?Song,?Xingjie?Hu, Chang?Liu, Jiye?Shi, Hui?Wang*,?Lixing?Zhan*,?Haiyun?Song*. Inhibition of Epithelial-Mesenchymal Transition and Tissue Regeneration by Waterborne Titanium Dioxide Nanoparticles, ACS Appl Mater Interfaces, 2018, 10(4): 3449-3458.
13.?Yi Zhou,?Renxu Chang,?Weiwei Ji,?Na Wang,?Meiyan Qi,?Yi Xu,?Jingyu?Guo,?Lixing Zhan *. Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance. Journal of Biological?Chemistry. 2016, 291(1):291-302.
14.?Yi Xu,?Renxu Chang,?Zhiyong Peng,?Yanmei Wang,?Weiwei Ji,?Jingyu Guo,?Lele Song,?Cheng?Dai,?Wei Wei,?Yanjun Wu,?Xinjian Wan,?Chenghao Shao,?Lixing Zhan*.??Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression.?Nat Commun.?2015,?6:7184.?
15.?Lixing Zhan,?Avi Rosenberg,?Kenneth C Bergami,?Min Yu,?Zhenyu Xuan,?Aron B Jaffe,?Craig Allred,?Senthil K Muthuswamy*. Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma. Cell. 2008, 135(5):865-78.
16.?Lixing Zhan, Bin Xiang, Senthil K. Muthuswamy*.Controlled Activation of ErbB1/ErbB2 Heterodimers Promote Invasion of Three-Dimensional Organized Epithelia in an ErbB1-Dependent Manner: Implications for Progression of ErbB2-Overexpressing Tumor.?Cancer Res. 2006, 66(10):5201-5208.
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